NEXARS is a research organization and our main mission is to carry out basic and applied research and experimental development and disseminate their results through teaching and education of students, publishing in renowned scientific journals and especially rapid transfer to practice.
Research
Research and Development
We research
and develop
We respond quickly
to new opportunities
We are developing cooperation
with public research institutions
FIELDS OF OUR RESEARCH
- Laboratory for research of the role of the microbiome for human health.
- Laboratory of development and preparation recombinant proteins for therapeutic and diagnostic purposes.
- Laboratory of development and preparation of biocompatible nanomaterials.
We study microorganisms and their metabolites, including prebiotics and postbiotics, in relation to human health.
We are the authors of 18 new microbial strains, of which two original biotechnological production strains are internationally protected under the Patent Procedure under the Budapest Treaty.
For our original strains, we perform shotgun sequencing of the entire genome – a sample of the publication in the GenBank database complete genom sequencing
We develop and prepare recombinant proteins expressed in eukaryotic and prokaryotic expression systems for vaccine development and production. We use modern bioreactors such as “rocking wave”, hollow fiber “and” stirred wessel “.
We cooperate with leading research institutions in the Czech Republic on the design and development of recombinant proteins.
We develop and prepare functionalized biocompatible nanomaterials as API carriers for pharmaceutical applications.
In our laboratory, we use technology that allows us to prepare various types of nanofibrous materials in a unique way by spinning from the free surface of a polymer solution in a strong electrostatic field.
We develop and prepare nanoparticulate drug carriers based on liposomes, lipodiscs and nanolipid emulsions using microfluidic high-pressure homogenization and microfluidic mixing.
In the field of nanotechnologies, we cooperate with renowned institutions in the country and worldwide.
The application of our nanocarriers in medicine is very wide, from vaccinations to the treatment of cancer.
AWARDS
Honorable mention in the competition for the Innovation Award of 2019.
Our company was chosen as a model for the meeting of the academic and state spheres of the Ministry of Industry and Trade of the Czech Republic.
Our Head of Research and Development Doc. RNDr. Jaroslav Turanek, DSc. is the holder of the Award of the Minister of Agriculture of the Czech Republic for the best realized result of research and experimental development in 2016 entitled "Safe adjuvants and liposomal carriers for the construction of recombinant vaccines"
Head of Research and Development Doc. RNDr. Jaroslav Turanek, DSc. and members of the Scientific Board of NEXARS prof. MUDr. Milan Raska, Ph.D. and doc. Ing. Irena Kratochvílová, Ph.D. are members of the team led by J. Turánek, who won 1st place in the TAČR competition Award in the category SOLUTIONS FOR QUALITY OF LIFE "Multiepitope synthetic vaccine against borreliosis for veterinary applications" (Award TA ČR 2015 - Vaccine against borreliosis).
CURRENT REASEARCH PROJECTS
FV20572 Adjuvant therapy
The main goal of the project is to supplement the existing cancer and COVID-19 therapy.
FV40233 – Research and development of processes of microbial hydrolysis for the preparation of components with high biological value
The aim of the project is to develop an immuno-nutritional intervention for risk patients (before / after surgery) or seniors with COVID-19.
FV40233 – Research and development of processes of microbial hydrolysis for the preparation of components with high biological value
The aim of the project is to look for ways to influence the production of neurotransmitters in the intestine through a microbiota and thus supplement the existing therapy without side effects.
FV40120 – Biotechnological production of biologically active substances for food and medical use
The project deals with the research of functional foods with health benefits and the minimization of the negative impacts of industrial processing.
FV40231 – Innovative platform for determination of bioactive compounds
The project deals with the possibility of non-invasive diagnostics using the latest technical means.
IP 073-20-18 – Development of a recombinant Covid-19 vaccine
Development of a recombinant Covid-19 vaccine and its preclinical studies.
CZ.01.1.02/0.0/0.0/20_338/0024139 – Project „REBIONVAC”
Establishment of a new research and innovation capacity focused on the preparation of recombinant proteins for therapeutic and diagnostic purposes in cleanrooms.
IP 073-20-21 – Development of pseudoviruses
Development of pseudoviruses (currently including new mutations) to improve testing of neutralizing antibodies in serum and increase the availability of blood plasma therapy from cured patients as an effective replacement for antibodies currently unavailable in the Czech Republic.
IP 073-21-08 – Transfer to the production of an internal project IP 073-20-18
Preparation of a recombinant Covid-19 vaccine (including new mutations) - formulated for injection.
IP 073-21-07 – Development of therapeutic monoclonal antibodies against SARS-CoV-2 and its variants
Development of therapeutic monoclonal antibodies (mAB) against SARS-CoV-2 using procedures and methods in vaccine development.
OUR RESEARCH AND DEVELOPMENT IN NUMBERS
3
Fields of research
and development
2000
m2 of laboratories
10
Current
projects
18
New microbial
strains
4
Products
on the market
2
papers in peer
reviewed journals
SCIENTIFIC COUNCIL
Our Scientific Council serves as an advisory body for strategic decision-making and concept development. It is composed of experts in the fields of immunology and immunotherapy, bio and nanotechnology, design and development of recombinant proteins, preclinical testing and GMP.